Quantitative Intravital Imaging
High resolution quantitative cell specific and subcellular analysis of drug biodistribution and pharmacokinetics in living animals visualizing:
- Characterization of the distribution of drugs between and within specific types of cells.
- Characterization of the mechanisms and kinetics of renal and hepatic drug clearance.
High resolution quantatitive assays of the physiological effects and toxicity of drugs of:
- Vascular diameters and volume
- Microvascular red blood cell flow rates
- Microvascular permeability
- White blood cell rolling and attachment
- Cell Death (apoptosis, necrosis)