Uptake of fluorescent agents within proximal tubule cells.

Blood flow in glomerular capillaries and their interstitium.

Formation of a tubular cast in the kidney of a living rat.

Real-time 3D image of vascular flow in GFP-expressing tumor in the prostate of a living mouse.

Accumulation of a fluorescent compound in Kuppfer cells of the liver of a living rat.

Vesicular accumulation of a fluorescent drug conjugate (red) by endothelial cells in the liver of a living rat.

Time series of renal accumulation and clearance of a fluorescently-labeled pharmaceutical. These images of the kidney of a living rat show that following glomerular filtration, the agent was then internalized into endocytic vesicles of proximal tubule cells. The drug was cleared from cells within 24 hours. The same animal can be restudied.